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Human & Experimental Toxicology
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Acute iron poisoning in adult female

A. Skoczynska

Department of Internal Medicine, Medical University of Wroclaw, Wroclaw, Poland, annaskoc{at}ak.am.wroc.pl

D. Kwiecinska

Department of Internal Medicine, Medical University of Wroclaw, Wroclaw, Poland

M. Kielbinski

Department of Hematology, Medical University of Wroclaw, Wroclaw, Poland

M. Lukaszewski

Department of Anaesthesiology and Intensive Therapy, Medical University of Wroclaw, Wroclaw, Poland

We report a case of a 27-year-old female with anemia, treated with high dose oral and parenteral iron therapy (within 20 days, the patient received a total dose of 4 g Fe+2 orally and 700 mg Fe+2 iv and im), and developed clinical manifestations characteristic of acute iron poisoning. Initial gastrointestinal symptoms and hypotension were followed by signs of mitochondrial toxicity: high leucocytosis, shock, multi-organ failure and disseminated intravascular coagulation. We discuss the difficulties in diagnosing acute iron poisoning. The initial low total iron blood capacity and high ferritin level, as well as the typical sequence of symptoms, supported the diagnosis. The patient avoided fatal consequences, probably due to the administration of iron doses over an extended period of time. However, cumulative effects led to the apparent iron toxicity. After 2 weeks of treatment, the patient was discharged from hospital in good condition. Human & Experimental Toxicology (2007) 26, 663-666

Key Words: acute poisoning • desferrioxamine • iron • SIRS

Human & Experimental Toxicology, Vol. 26, No. 8, 663-666 (2007)
DOI: 10.1177/0960327107071854
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