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Human & Experimental Toxicology, Vol. 26, No. 8, 637-643 (2007)
DOI: 10.1177/0960327107076323

Effects of amphetamine and cocaine on the development of acute experimental allergic encephalomyelitis in Lewis rats

María J Núñez

Neuroimmunology Laboratory, Department of Pharmacology, School of Medicine, Dentistry and Nursing, C/San Francisco, s/n. 15782 Santiago de Compostela, A Coruña, Spain

José Balboa

Neuroimmunology Laboratory, Department of Pharmacology, School of Medicine, Dentistry and Nursing, C/San Francisco, s/n. 15782 Santiago de Compostela, A Coruña, Spain

Manuel Rey-Méndez

Neuroimmunology Laboratory, Department of Pharmacology, School of Medicine, Dentistry and Nursing, C/San Francisco, s/n. 15782 Santiago de Compostela, A Coruña, Spain

Julio Brenlla

Neuroimmunology Laboratory, Department of Pharmacology, School of Medicine, Dentistry and Nursing, C/San Francisco, s/n. 15782 Santiago de Compostela, A Coruña, Spain

Mercedes González-Peteiro

Neuroimmunology Laboratory, Department of Pharmacology, School of Medicine, Dentistry and Nursing, C/San Francisco, s/n. 15782 Santiago de Compostela, A Coruña, Spain

Elena Rodrigo

Neuroimmunology Laboratory, Department of Pharmacology, School of Medicine, Dentistry and Nursing, C/San Francisco, s/n. 15782 Santiago de Compostela, A Coruña, Spain

Manuel Freire-Garabal

Neuroimmunology Laboratory, Department of Pharmacology, School of Medicine, Dentistry and Nursing, C/San Francisco, s/n. 15782 Santiago de Compostela, A Coruña, Spain, fffregar{at}usc.es

The present experiment deals with the effects of amphetamine and cocaine on the development and course of experimental allergic encephalomyelitis (EAE) induced in Lewis rats. Rats were immunized at the age of eight weeks with purified myelin basic protein isolated from guinea pig brain in complete Freund's adjuvant. Drug administration and recording of EAE clinical signs was performed daily since day 1 post-immunization (PI). On day 14 and 28 PI, six rats per group were bled and sacrificed. Spinal cord was examined histologically for EAE lesions. In vivo administration of 0.5 and 1 mg/Kg of amphetamine or cocaine resulted in a dose-related enhancement of neurological and histological signs of acute EAE in comparison with control rats. Both drugs caused a reduction of latent period together with a delayed regression of neurological signs along with an increase in inflammation in the central nervous system in comparison with placebo. Human & Experimental Toxicology (2007) 26, 637—643

Key Words: amphetamine • cocaine • experimental autoimmune encephalomyelitis (EAE) • multiple sclerosis


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