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A retrospective evaluation of analgesic exposures from Izmir, Turkey

Department of Pharmacology, School of Medicine, Dokuz Eylul University, Izmir, Turkey

Sule Kalkan

Department of Pharmacology, School of Medicine, Dokuz Eylul University, Izmir, Turkey

Aylin Akgun

Department of Pharmacology, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey

Sedat Capar

Faculty of Arts and Sciences, Department of Statistics, Dokuz Eylul University, Izmir, Turkey

Yesim Tuncok

Department of Pharmacology, School of Medicine, Dokuz Eylul University, Izmir, Turkey, yesim.tuncok{at}deu.edu.tr

The objective of this study is to analyze exposures concerning analgesics that were reported to Dokuz Eylul University Drug and Poison Information Center (DPIC) and admitted to the Department of Emergency Medicine in Dokuz Eylul University Hospital (EMDEU) between 1993 and 2004. Demographics of the patients, characteristics of analgesic exposures, performed treatment attempts and outcome of the poisoned patients were recorded on standard data forms and were then entered into a computerized database program. Statistical analysis was performed by using the chi-square test. The DPIC recorded 55 962 poisoning calls, 48 654 (86.9%) of them related to medicines. Analgesics accounted for 16.3% (7 939 cases) of all medicine-related exposures; among them 446 exposures were admitted to EMDEU. More than half of the analgesic exposure calls and admitted cases involved adults (55.9%, 4 440). Females dominated in all age groups (70.3%, 5 578). Mean age was 20.2 ± 11.8. The most involved analgesics were paracetamol (47.9%), propionic acid derivatives (16.1%) and salicylates (13.7%). Most of the poisonings were intentional (75.1%), especially in 19—29 years age group of adults and 13—18 years age group of children. Most of the patients reported to DPIC and admitted to EMDEU were asymptomatic (84.4% and 54.7%, respectively). Gastrointestinal decontamination methods were performed more frequently for admitted poisoning cases before hospital admission than reported poisoning cases (61% vs. 23%). Paracetamol ingestion was the most common cause of analgesic exposures reported to our DPIC. Most of the analgesic exposures reported to DPIC were asymptomatic or mild. DPICs have an important role for the referral of analgesic exposures without unnecessary gastrointestinal decontamination procedures. Human & Experimental Toxicology (2007) 26, 629—636

Key Words: analgesic exposures • Drug and Poison Information Center • paracetamol • salicylate

Human & Experimental Toxicology, Vol. 26, No. 8, 629-636 (2007)
DOI: 10.1177/0960327107076836


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