This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Talaie, H. Articles by Tghaddosinezhad, M. Search for Related Content PubMed PubMed Citation Articles by Talaie, H. Articles by Tghaddosinezhad, M. Social Bookmarking                   What's this?

Rhabdomyolysis among acute human poisoning cases

Toxicological Research Center, Loghman-Hakim Hospital, School of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

A. Pajouhmand

Toxicological Research Center, Loghman-Hakim Hospital, School of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

M. Abdollahi

Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

R. Panahandeh

Toxicological Research Center, Loghman-Hakim Hospital, School of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

H. Emami

National Research Institute of Tuberculosis and Lung Diseases, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

S. Hajinasrolah

National Research Institute of Tuberculosis and Lung Diseases, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

M. Tghaddosinezhad

Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

Rhabdomyolysis is a clinical and biochemical syndrome occurring when skeletal muscle cells erupt and result in release of creatine phosphokinase (CPK), lactate dehydrogenase (LDH) and myoglobin into the interstitial space and plasma. Mechanical trauma, compression, excessive muscle activity and ischemia are frequent causes, but non-traumatic rhabdomyolysis is usually caused by a toxic reaction to drugs.

In this study, 181 patients suspected of rhabdomyolysis were admitted to the poisoning center of Loghman-Hakim Hospital in Tehran during one year (September 2004 to September 2005) were studied. Patients were included on the basis of physical examination and blood analysis for CPK and LDH. Rhabdomyolysis was confirmed if CPK level has been greater than 975 U/L. Out of 181 patients, 64 were female and 117 were male with an age range between 13—78 years. One-hundred and forty-three (79%) patients had CPK greater than 975 U/L. In 6% of the cases, multiple drug poisoning were observed. Two patients (1.1%) had muscle pain, five patients (2.8%) had rigidity and five patients (2.8%) had muscle inflammation. One-hundred and nineteen patients (65.7%) were febrile. The most common cause of rhabdomyolysis was opium. Blood ALT showed an increase in 109 patients (60.9%), AST in 80 patients (44.7%), and LDH in 144 patients (79.6%). Fifty patients (28.2%) had higher blood direct bilirubin and 64 patients (36.4%) showed higher total bilirubin. Six percent of patients had been diagnosed as ARF by indication of creatinine greater than 1.4 mg/dL. Five percent of patients had hypernatremia and 1.1% of patients had hyperkalemia.

It is concluded that rhabdomyolysis is a matter of concern in human poisonings and needs special approach to attend. Human & Experimental Toxicology (2007) 26: 557—561.

Key Words: chemical • drug • poisoning • rhabdomyolysis

Human & Experimental Toxicology, Vol. 26, No. 7, 557-561 (2007)
DOI: 10.1177/0960327107078667


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?