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Human & Experimental Toxicology
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Adult lisinopril ingestions reported to Texas poison control centers, 1998—2005

Mathias B. Forrester

Texas Department of State Health Services, 1100 W 49th Street, Austin, TX 78756, USA, mathias.forrester{at}dshs.state.tx.us

There is limited information on potentially adverse lisinopril ingestions reported to poison control centers. Using adult lisinopril ingestions reported to Texas poison control centers during 1998—2005, the proportion of cases involving serious outcomes was determined for selected variables and evaluated for statistical significance by calculating the rate ratio (RR) and 95% confidence interval (CI). Of 468 cases identified, 43 (9%) involved serious outcomes. The severity of the outcome associated with adult lisinopril ingestions depended on the dose and the circumstances of the ingestion. Thus, serious outcomes were significantly more likely to occur with a maximum dose >80 mg (RR 5.69, CI 2.43—13.33) or, if the dose was unknown, ≥3 tablets (RR 9.57, CI 2.39—54.97), where the circumstances of the exposures involved self-harm or malicious intent (RR 6.96, CI 3.65—13.31), or the patient was already at or en route to a health care facility when the poison control center was contacted (RR 7.33, CI 3.09—17.85) or referred to a health care facility by the poison control center (RR 23.76, CI 10.62—55.67). The management of patients with severe outcomes was more likely to involve health care facilities. Such information is useful for creating of triage guidelines for the management of adult lisinopril ingestions. Human & Experimental Toxicology (2007) 26, 483—489

Key Words: adverse exposures • lisinopril • management • poison control centers

Human & Experimental Toxicology, Vol. 26, No. 6, 483-489 (2007)
DOI: 10.1177/0960327107073416


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This article has been cited by other articles:


Home page
Hum Exp ToxicolHome page
B. Farmer, J. Prosser, and R. Hoffman
Letter to the Editor
Human and Experimental Toxicology, October 1, 2008; 27(10): 737 - 737.
[PDF]


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Hum Exp ToxicolHome page
M Forrester
Reply to comments on escitalopram and lisinopril ingestion articles
Human and Experimental Toxicology, October 1, 2008; 27(10): 739 - 739.
[PDF]



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