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Human & Experimental Toxicology
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Pharmacology and Toxicology of Bupleurum Root-Containing Kampo Medicines in Clinical Use

F Ikegami

Center for Environment, Health and Field Sciences, Chiba University, Kashiwanoha 6-2-1, Kashiwa 277-0882, Japan, ikegami{at}faculty.chiba-u.jp

M Sumino

Center for Environment, Health and Field Sciences, Chiba University, Kashiwanoha 6-2-1, Kashiwa 277-0882, Japan

Y Fujii

Faculty of Pharmacy, Ohu University, Misumido 31-1, Tomita-machi, Koriyama 963-8611, Japan

T Akiba

Department of Kampo Medicine, Keio University School of Medicine, Shinano-machi 35, Shinjuku-ku, Tokyo 160-8582, Japan

T Satoh

HAB Research Institute, Cornea Center Bldg., Ichikawa General Hospital, Sugano 5-11-13, Ichikawa 272-8513, Japan

Kampo (Japanese traditional herbal) medicines have been produced by combining multiple crude drugs, almost all of plant origin but with some of animal or mineral origin, and contain a great many substances. Their effect is a combination of the various interactions of the constituent substances, whether they are enhancing, synergistic or suppressive. Kampo medicine has an overall effect that is different from the combined effects of individual crude drugs, and several side effects such as anorexia, slight fever and nausea have been reported in the treatment of certain disorders and disease states with Kampo medicines. Among 210 medical formulations used in Japan, some relevant information on the clinical uses, pharmacology and toxicology of six manufactured Kampo medical formulations, Shosaikoto, Daisaikoto, Saikokeishito, Hochuekkito, Saibokuto and Saireito, containing Bupleurum root are reviewed. Studies of some potential interactions between Kampo medicine and western drugs are also considered.

Key Words: Japanese traditional herbal medicine • Kampo medicine • clinical toxicology • pharmacology • drug toxicity • Bupleurum root

Human & Experimental Toxicology, Vol. 25, No. 8, 481-494 (2006)
DOI: 10.1191/0960327106het654oa
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