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Effect of prenatal exposure to bisphenol A on the serum testosterone concentration of rats at birth

Institute of Experimental Animals, St Marianna University Graduate School of Medicine, Kawasaki, Kanagawa 216-8511, Japanm3tanaka{at}marianna-u.ac.jp; Department of Pharmacology, St Marianna University School of Medicine, Kawasaki, Kanagawa 216-8511, Japan; CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan

S Nakaya

Department of Pharmacology, St Marianna University School of Medicine, Kawasaki, Kanagawa 216-8511, Japan

M Katayama

Department of Functional Bioanalysis, Meiji Pharmaceutical University, Kiyose, Tokyo 204-8533, Japan

H Leffers

University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, DK-2100, Denmark; CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan

S Nozawa

Department of Urology, St Marianna University School of Medicine, Kawasaki, Kanagawa 216-8511, Japan; CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan

R Nakazawa

Department of Urology, St Marianna University School of Medicine, Kawasaki, Kanagawa 216-8511, Japan

T Iwamoto

Department of Urology, St Marianna University School of Medicine, Kawasaki, Kanagawa 216-8511, Japan; CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan

S Kobayashi

Department of Pharmacology, St Marianna University School of Medicine, Kawasaki, Kanagawa 216-8511, Japan

In the rat, testosterone (T) in the neonatal period plays an important role in sexual differentiation and there is a serum T surge in male rats 2 hours after birth. Pregnant female rats were exposed to various doses of bisphenol A (BPA) from gestational day 1 (GD1) through 2 hours after parturition. About half of the BPA-exposed and control dams were subjected to cesarean section on GD22. The male fetuses on GD22 were immediately sacrificed and blood was collected. The other half of the BPA-treated and control dams delivered at GD23 (parturition day). The male pups were sacrificed 2 hours after birth. Serum T concentration was determined by radioimmunoassay (RIA). The BPA concentration in the fetal serum on GD22 increased inversely to the T levels in the serum. The T concentration in the pups' serum 2 hours after birth decreased inversely to the BPA concentration in the serum. However, there were no differences in the serum T concentration among the various doses of BPA. These results suggest that exposure to BPA in utero inhibits the T surge in the neonatal period and we speculate that exposure to BPA in utero disrupts the endocrine environment in the neonatal male.

Key Words: bisphenol A • in utero • male rat • neonatal rat • prenatal period • testosterone

Human & Experimental Toxicology, Vol. 25, No. 7, 369-373 (2006)
DOI: 10.1191/0960327106ht638oa


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