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Human & Experimental Toxicology
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Effect of chromium on vertebrae, femur and calvaria of adult male rats

S Sankaramanivel

Department of Endocrinology, Dr ALM Post Graduate Institute of Basic Medical Sciences, Taramani, University of Madras, Chennai 600 113, India; Biochemistry Laboratory, Central Leather Research Institute, Adyar, Chennai-20, India; sankarmv{at}hotmail.com

R Jeyapriya

D Hemalatha

S Djody

J Arunakaran

N Srinivasan

Department of Endocrinology, Dr ALM Post Graduate Institute of Basic Medical Sciences, Taramani, University of Madras, Chennai 600 113, India

Alloys of chromium have a long history of success in the surgical treatment of many orthopaedic defects. Nonetheless, prostheses loosening are commonly found around arthoplasties due to corrosion of metals. On this basis, it is hypothesized that chromium accumulation interferes with remodeling of bone. The present study aims to analyse the toxic effects of chromium on bone phosphatases in various regions of the bone in rats. Rats were treated with chromium intraperitoneally (0.5 mg/kg) in the form of potassium dichromate for 5 days. The accumulation of chromium is approximately 5.2-fold in the vertebrae, 8.9-fold in the femur and 8.7-fold in the calvaria, when compared to control. Chromium administration significantly reduced the activity of enzymes, eg, alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP). The study revealed a significant increase in the concentration of calcium, altered bone formation rate and bone morphology in the femur, vertebrae and calvaria. The interesting findings of the current study suggest altered bone turnover.

Key Words: acid phosphatase • alkaline phosphatase • bone • bone turnover • chromium

Human & Experimental Toxicology, Vol. 25, No. 6, 311-318 (2006)
DOI: 10.1191/0960327105ht627oa
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