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Human & Experimental Toxicology
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A high-performance liquid chromatography method for hypoxanthine determination in vitreous humour: application to estimation of post mortem interval

J I Muñoz

Department of Pathology and Forensic Sciences, University of Santiago de Compostela, Spain; Departamento de Anatomía Patológica y Ciencias Forenses, Facultad de Medicina, C/ San Francisco s/n, 15705 Santiago de Compostela, Galicia, Spain

E Costas

M S Rodrlguez-Calvo

J M Suárez-Peñaranda

M López-Rivadulla

L Concheiro

Department of Pathology and Forensic Sciences, University of Santiago de Compostela, Spain

We have developed a new technique to determine the concentration of hypoxanthine [Hx] in a reverse phase column using a modified high-performance liquid chromatography (HPLC) method that is faster and more reliable than those previously described. In this paper we present a formula for estimating the post mortem interval (PMI) based on this HPLC method by applying the inverse prediction method. The regression line obtained by changing the variables gives PMI=0.183[Hx]+0.599 (PMI in hours, [Hx] in µmol/L, R2-0.531, P-0.05).

Key Words: HPLC • hypoxanthine • post mortem interval • regression line • vitreous humour

Human & Experimental Toxicology, Vol. 25, No. 5, 279-281 (2006)
DOI: 10.1191/0960327106ht615oa
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