This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Collicchio-Zuanaze, R C Articles by Crocci, A J Search for Related Content PubMed PubMed Citation Articles by Collicchio-Zuanaze, R C Articles by Crocci, A J Social Bookmarking                         What's this?

Calcium gluconate and sodium succinate for therapy of sodium fluoroacetate experimental intoxication in cats: clinical and electrocardiographic evaluation

Department of Veterinary Clinic, Faculty of Veterinary Medicine and Animal Science of the Sã o Paulo State University - UNESP, Botucatu, Brazil; Departmento de Clínica Veterinária Faculdade de Medicina Veterinária e Zootecnia, UNESP - Campus de Botucatu, Caixa Postal 560, CEP 18618-000, Distrito de Rubião Jr. - Botucatu - SP Brasil ritacollizuanaze{at}yahoo.com.br

M Sakate

D S Schwartz

Department of Veterinary Clinic, Faculty of Veterinary Medicine and Animal Science of the Sã o Paulo State University - UNESP, Botucatu, Brazil

E Trezza

Department of Medical Clinic, School of Medicine - UNESP, Botucatu, Brazil

A J Crocci

Department of Biostatistics, Bioscience Institute - UNESP, Botucatu, Brazil

Sodium fluoroacetate (SFAC) or Compound 1080 is a potent rodenticide, largely used after 1946 for rodent and home pest control. The toxic effects of SFAC are caused by fluorocitrate action, a toxic metabolite, which has a competitive action with aconitase enzyme, leading to citrate accumulation and resulting in interference in energy production by Krebs cycle blockade. In the present study, domestic cats were intoxicated with oral doses of fluoroacetate (0.45 mg/kg). The intoxicated animals presented emesis, diarrhea with abdominal pain posture and an abdominal palpation, tachypnea, bilateral midriasis, hypothermia, hyperexcitability and convulsions. Blood gas analysis indicated decreased pH and bicarbonate levels. Serum ionized calcium was also decreased. ECG showed non–specific changes in ventricular repolarization and ventricular arrhythmias. The survival rate was 75% in the treated group with calcium gluconate and sodium succinate and 37.5% in the nontreated group.

Key Words: calcium gluconate • cats • electrocardiography • sodium fluoroacetate • sodium succinate

Human & Experimental Toxicology, Vol. 25, No. 4, 175-182 (2006)
DOI: 10.1191/0960327106ht609oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?