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Human & Experimental Toxicology
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Terminalia chebula (fruit) prevents liver toxicity caused by sub-chronic administration of rifampicin, isoniazid and pyrazinamide in combination

S A Tasduq

K Singh

N K Satti

D K Gupta

K A Suri

Division of Pharmacology and Natural Products Chemistry, Regional Research Laboratory, (CSIR), Canal Road, Jammu–Tawi 180 001, India

R K Johri

Division of Pharmacology and Natural Products Chemistry, Regional Research Laboratory, (CSIR), Canal Road, Jammu–Tawi 180 001, India; rakeshkjohri{at}rediffmail.com

Terminalia chebula Gertn. (Combetraceae) is an important herbal drug in Ayurvedic pharmacopea. In the present study, a 95% ethanolic extract of T. chebula (fruit) (TC extract), which was chemically characterized on the basis of chebuloside II as a marker, was investigated for hepatoprotective activity against anti-tuberculosis (anti-TB) drug-induced toxicity. TC extract was found to prevent the hepatotoxicity caused by the administration of rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA) (in combination) in a sub-chronic mode (12 weeks). The hepatoprotective effect of TC extract could be attributed to its prominent anti-oxidative and membrane stabilizing activities. The changes in biochemical observations were supported by histological profile.

Key Words: anti-oxidant • chebuloside II • hepatotoxicity • isoniazid • pyrazinamide • rifampicin • Terminalia chebula

Human & Experimental Toxicology, Vol. 25, No. 3, 111-118 (2006)
DOI: 10.1191/0960327106ht601oa
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