Human & Experimental Toxicology

 

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Human & Experimental Toxicology, Vol. 25, No. 10, 613-617 (2006)
DOI: 10.1177/096032706072472

Acute amitraz intoxication: retrospective analysis of 45 cases

Y Demirel

Department of Family Medicine, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey, ydemirel{at}cumhuriyet.edu.tr

A Yilmaz

Department of Internal Medicine, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey

S Gursoy

K Kaygusuz

C Mimaroglu

Department of Anesthesiology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey

Objective: To present special clinical and laboratory features of 45 cases (44 adult cases) who were intoxicated through oral route. Design: Retrospective study. Setting: Intensive care unit (ICU) of a university hospital. Patients: Forty-five patients admitted to the ICU of Cumhuriyet University Hospital. Results: Forty-five patients between 4 and 97 years of age were evaluated. Intoxication was the result of a suicide attempt in 67% of cases and accidental in 33% of cases. Unconsciousness, nausea and vomiting were the common initial symptoms. The major clinical findings in the ICU were bradycardia, myosis, hypothermia, hyperglycemia, hypotension, coma and respiratory depression. Blood glucose level was increased in 64% of cases. No problem was noted in the patient or the fetus in a pregnant, 27-year-old patient, who was intoxicated with 10 mL of 12.5% amitraz. The length of stay in the ICU was between 2 and 15 days. None of the patients died. All patients were discharged without neurological sequela. Conclusion: The prognosis of amitraz intoxications through oral route is benign and results in complete healing; however, we suggest that these cases should be well monitored and followed-up in ICUs.


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