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Immunocytogenetic effects of gonadotropin releasing hormone analogue: Triptorelin Pamoate (Decapeptyl ®) during in vitro fertilization treatment

K M Al-Qaoud

Department of Biological Sciences, Yarmouk University, Irbid, Jordan

M Ja'fer

IVF Unit, The Islamic Hospital, Amman, Jordan

A M Khalil

Department of Biological Sciences, Yarmouk University, Irbid, Jordan ahmad200121163{at}yahoo.com

In this study, the immunocytogenetic effects of Decapeptyl ® (Triptorelin Pamoate) were assessed in the peripheral blood lymphocytes of females undergoing in vitro fertilization (IVF) treatment. Blood samples were taken from 34 females (23 treated and 11 controls), cultured and examined for sister chromatid exchanges (SCE) and cell replication index (CRI). The SCE frequency increased around ovulation time in the controls, and around the time of human chorionic gonadotropin administration in the IVF group. However, the SCE rate was significantly higher in the latter group. Furthermore, the white blood cells (WBC) count was significantly higher on the day of ovum pick up compared to the day preceding luteinizing hormone (LH) and follicle stimulating hormone (FSH) treatment. Similar observations were recorded with respect to phagocytic activity tested by nitroblue tetrazolium (NBT) assay. The nitric oxide production abilities of macrophages were not significantly changed in the LH, FSH-treated group relative to its control. Finally, the 50% complement hemolytic activity (CH50) assay results indicated that Decapeptyl lacks a significant potential to affect the complement system.

Key Words: Decapeptyl • immunocytogenetics • in vitro fertilization • Triptorelin Pamoate

Human & Experimental Toxicology, Vol. 25, No. 10, 593-597 (2006)
DOI: 10.1177/096032706072462


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