This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Moreira, C Q Articles by Moreira, E G Search for Related Content PubMed PubMed Citation Articles by Moreira, C Q Articles by Moreira, E G Social Bookmarking                         What's this?

Developmental exposure to fenproporex: reproductive and morphological evaluation

Department of Biology, Center of Biological Sciences, Londrina State University, Londrina, PR, Brazil

M JSS Faria

Department of Biology, Center of Biological Sciences, Londrina State University; CP 6001, 86051-990, Londrina, PR, Brazil maze{at}uel.br

J E Baroneza

R J Oliveira

Department of Biology, Center of Biological Sciences, Londrina State University, Londrina, PR, Brazil

E G Moreira

Department of Physiological Sciences, Center of Biological Sciences, Londrina State University, Londrina, PR, Brazil

This study was designed to evaluate the maternal toxicity and teratogenicity of fenproporex, one of the most widelyused anorectic drugs in many countries, including Brazil. Three periods of exposure were evaluated: (a) 30 days before mating; (b) from gestational day (GD) 0 to 14; and (c) 30 days before mating and during pregnancy, until GD 14. Female mice from experimental groups received, by gavage, 15 mg/kg of fenproporex. Treatment with fenproporex increased ambulation of dams in the open field test and did not influence the mobility in the forcedswimming test. There was no significant difference in maternal weight gain between the controls and fenproporex-treated groups, although fenproporex treatment reduced the gravid uterus weight. No significant difference was observed in postimplantation loss, fetal viability and sex ratio. In addition, this compound did not impair intra-uterine growth. The reduction in the number of implantations in the groups receiving fenproporex indicates that this drug may have an adverse effect on implantation. Fenproporex treatment also increased the number of fetuses presenting small kidneys and cervical ribs. The present results indicate that fenproporex, in the dose and exposure periods tested, appears to exhibit a low maternal toxicity and teratogenic potential in mice.

Key Words: amphetamine • fenproporex • maternal toxicity • pregnancy • teratogenicity

Human & Experimental Toxicology, Vol. 24, No. 8, 397-402 (2005)
DOI: 10.1191/0960327105ht545oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				C Q Moreira, M J. Faria, and E G Moreira Behavioral neurotoxicity in adolescent and adult mice exposed to fenproporex during pregnancy Human and Experimental Toxicology, August 1, 2005; 24(8): 403 - 408. [Abstract] [PDF]