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Human & Experimental Toxicology
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*AMLODIPINE BESYLATE
*METARAMINOL
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Metaraminol (Aramine®) in the management of a significant amlodipine overdose

D M Wood

Pharmacology and Clinical Pharmacology, Department of Basic Medical Sciences, St George’s Hospital Medical School, Jenner Wing, Cranmer Terrace; National Poisons Information Service (London), Guy’s and St Thomas’ Hospital; London SW17 0RE, UK; dwood{at}sghms.ac.uk

K D Wright

The Royal Surrey County Hospital NHS Trust, Guildford, UK

A L Jones

P I Dargan

National Poisons Information Service (London), Guy’s and St Thomas’ Hospital, London, UK

Objective: To report a patient with a significant amlodipine self-poisoning who failed to clinically respond to conventional treatment and was managed with metaraminol (Aramine®). Patient: A 43-year old male presenting after ingestion of 560 mg amlodipine, who failed to respond clinically to treatment with fluid resuscitation, calcium salts, glucagon and norepinephrine/epinephrine inotropic support. Main results: Following a loading bolus of 2 mg and intravenous infusion (83 mg/min) of metaraminol (Aramine®) there was improvement in his blood pressure, cardiac output and urine output. Conclusions: This is the first case report of the beneficial use of metaraminol (aramine) in the management of significant amlodipine poisoning unresponsive to conventional therapy.

Key Words: amlodipine • aramine • calcium channel blockers • metaraminol • overdose

Human & Experimental Toxicology, Vol. 24, No. 7, 377-381 (2005)
DOI: 10.1191/0960327105ht538oa
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