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Human & Experimental Toxicology
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*ACEPHATE
*CHLORPYRIFOS
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Extremely sensitive biomarker of acute organophosphorus insecticide exposure

Yasuhiro Fujikawa

Drug Safety Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba-shi, Ibaraki, Japan 300-2635. y-fujikawa{at}hhc.eisai.co.jp

Tetsuo Satoh

Chiba University; HAB Research Laboratories, Chiba, Japan

Akiyoshi Suganuma

Drug Safety Research Laboratories, Eisai Co. Ltd., Ibaraki, Japan

Satoshi Suzuki

Yasuko Niikura

Shinobu Yui

HAB Research Laboratories, Chiba, Japan

Yoshiro Yamaura

Nagano Women’s Junior College, Nagano, Japan

Egasyn-ßglucuronidase complex is located at the luminal site of liver microsomal endoplasmic reticulum. When organophosphorus insecticides (OP) are incorporated into the liver microsomes, they become tightly bound to egasyn, a carboxylesterase isozyme, and subsequently, ß-glucuronidase (BG) is dissociated and released into blood. Consequently, the increase in plasma BG activity becomes a good biomarker of OP exposure. Thus, the single administration of EPN (O-ethyl O-p-nitrophenylphenylphosphonothioate), acephate and chlorpyrifos increased plasma BG activity in approximately 100-fold the control level in rats. The increase in plasma BG activity after OP exposure is a much more sensitive biomarker of acute OP exposure than acetylcholinesterase (AChE) inhibition.

Key Words: carboxylesterase • egasyn • ß-glucuronidase • organophosphorus insecticide

Human & Experimental Toxicology, Vol. 24, No. 6, 333-336 (2005)
DOI: 10.1191/0960327105ht532oa
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This article has been cited by other articles:


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Blood {beta}-glucuronidase as a suitable biomarker at acute exposure of severe organophosphorus poisoning in human
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[Abstract] [PDF]


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