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Human & Experimental Toxicology
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Lipids, lipid peroxidation and 7-ketocholesterol in workers exposed to lead

Slawomir Kasperczyk

Department of Biochemistry, Silesian Medical University in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland skasperczyk{at}slam.katowice.pl

Ewa Birkner

Aleksandra Kasperczyk

Department of Biochemistry, Silesian Medical University in Katowice, Zabrze, Poland

Janusz Kasperczyk

Department and Institute of Medicine and Environmental Epidemiology, Silesian Medical University in Katowice, Zabrze, Poland

The study population included healthy men and hypertensive employees of zinc and lead steelworks in the south of Poland. Workers exposed to lead (n=137) were divided into two groups: the first included employees with low exposure to lead (LL) with mean blood lead (PbB) 25-40 µg/dL and the second one with PbB over 40 µg/dL (HL group). The administration workers (n=35) were the control group. Evaluation of lipids and oxidative changes of cholesterol and lipids were estimated in blood samples. No significant changes in concentration of 7-ketocholesterol and blood lipids (cholesterol, HDL, LDL, triglycerides) were found. Lipid peroxidation (LP) was significantly higher in both exposed groups in plasma and in the HL group in erythrocytes when compared with control. There can be two independent sources of LP increase: the first is connected with the direct effect of lead’s ions on erythrocytes, the second is the prooxidative effect of delta-aminolevulinic acid. Hypertension in the HL group when compared with people with PbB below 40 µg/dL (OR 4.4, 95%CI 1.4-40 mg/dL was found more often. LP significantly increased by about 71% and concentration of 7-ketocholesterol by about 122% in hypertensives when compared with normotensives in the HL group.

Key Words: 7-ketocholesterols • delta-aminolevulinic acid • hypertension • lead • lipid peroxidation

Human & Experimental Toxicology, Vol. 24, No. 6, 287-295 (2005)
DOI: 10.1191/0960327105ht528oa
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