Human & Experimental Toxicology

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rozman, K. K
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rozman, K. K
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Human & Experimental Toxicology, Vol. 24, No. 5, 255-257 (2005)
DOI: 10.1191/0960327105ht522oa

Hormesis and risk assessment

Karl K Rozman

Section of Environmental Toxicology, GSF-Institut für Toxikologie, Neuherberg, Germany; Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 1018 Breidenthal Building, Mail Stop 1018, 3901 Rainbow Boulevard, Kansas City, KS 66160-7417, USA; krozman{at}kumc.edu

It is postulated in this paper that at low doses all chemicals have hormetic/hormoligotic (beneficial) effects in living organisms. It has been known since Paracelsus that at high doses all chemicals are toxic. The combination of low and high dose effects can be empirically described by a ß-curve or an inverted ß-curve. A mathematical method is suggested to determine the maximum of the ß-curve or the minimum of the inverted ß-curve, yielding a point estimate for risk assessment.

Key Words: ß-curve • dose-response • hormesis • risk assessment


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Hum Exp ToxicolHome page
W J Waddell
Critique of dose response in carcinogenesis
Human and Experimental Toxicology, July 1, 2006; 25(7): 413 - 436.
[Abstract] [PDF]

Home page
 Hum Exp ToxicolHome page
B. G Callahan
Can hormesis be a default for dose-response?
Human and Experimental Toxicology, May 1, 2005; 24(5): 271 - 273.
[Abstract] [PDF]