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Human & Experimental Toxicology, Vol. 24, No. 12, 623-630 (2005)
DOI: 10.1191/0960327105ht575oa

Tissue levels of cadmium and trace elements in patients with myoma and uterine cancer

M Nasiadek

Department of Toxicology, Medical University of Lodz, Poland, Muszynskiego 1, 90-151 Lodz, Polandmnasiadek{at}pharm.am.lodz.pl

T Krawczyk

Polish Mother's Memorial Hospital, Research Institute, Lodz, Poland

A Sapota

Department of Toxicology, Medical University of Lodz, Poland

The aim of this study was to investigate the cadmium (Cd), copper (Cu), zinc (Zn), iron (Fe), magnesium (Mg) and calcium (Ca) concentrations in uterine cancer and uterine myoma. Tissue levels of six elements in 15 uterine cancers and 28 uterine myomas were measured by atomic absorption spectrometry. The samples were collected from women aged 32-79 (uterine myomas, uterine cancer and non-lesion uterine tissues from the same women). The results showed that the tissue Cd concentration was significantly lower in myoma than in non-lesion tissue. In uterine cancer, however, it was statistically significant, but only slightly lower than controls (the non-lesion uterine tissue). In the investigated tissues, the correlation between Cd concentration and age was found, but no effect of menopausal status or smoking habits on Cd level was detected. In uterine cancer tissue, a significant increase in Ca concentration and an insignificant increase in Mg level was observed when compared to normal uterine tissue. In uterine myoma, a significant increase of Mg and Mg/Ca ratio, as well as a decrease in Fe concentration were found. Statistical analysis showed no correlation between smoking habits, age, menopausal status and concentration of Cu, Zn, Fe, Mg and Ca trace metals in myoma or cancer tissue.

Key Words: cadmium • cancer • myoma • trace elements • uterine


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