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Human & Experimental Toxicology
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The effect of plasmapheresis on plasma cholinesterase levels in a patient with organophosphate poisoning

Muhammet Güven

Department of Intensive Care, Erciyes University, Faculty of Medicine, 38039 Kayseri, Turkey mguven{at}erciyes.edu.tr

Murat Sungur

Bülent Eser

Department of Intensive Care, Erciyes University, Faculty of Medicine, 38039 Kayseri, Turkey

Objective: To describe the role of plasmapheresis in management of organophosphate poisonings. Design: Case report. Setting: A medical intensive care unit of a medical faculty. Patient: A patient with organophosphate poisoning whose cholinesterase levels continuously decline and then increase up to a normal level after plasmapheresis is performed for his sepsis. Interventions: Plasmapheresis with fresh frozen plasma. Measurements and main results: Baseline plasma cholinesterase (ChE) level was 4001 IU/L (normal values: 4000-10000 IU/L). Aspiration pneumonia was developed on day 3, and sepsis occurred on day 5. During this period, ChE levels gradually decreased. On day 5, plasmapheresis was performed for sepsis. Interestingly, plasma ChE levels increased from 2101 IU/L to 6144 IU/L after plasmapheresis. Atropine and pralidoxime were stopped, and a high level of ChE continued during hospitalization. The patient was successfully weaned from mechanical ventilation 3 days after plasmapheresis. Conclusion: Plasma exchange therapy may be considered for patients with organophosphate poisoning unresponsive to atropine and pralidoxime.

Key Words: atropine • cholinesterase • organophosphate • oxime • plasmapheresis • poisoning

Human & Experimental Toxicology, Vol. 23, No. 7, 365-368 (2004)
DOI: 10.1191/0960327104ht462cr
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