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Human & Experimental Toxicology, Vol. 23, No. 5, 251-256 (2004)
DOI: 10.1191/0960327104ht443oa

Prevention of acute adriamycin cardiotoxicity by dantrolene in rats

Mehmet Emin Büyükokuroglu

Atatürk University, Faculty of Medicine, Department of Pharmacology, TR-25240 Erzurum, Turkey memin{at}atauni.edu.tr

Seyithan Taysi

Department of Biochemistry, Atatürk University, Faculty of Medicine, Erzurum, Turkey

Mustafa Buyukavci

Department of Pediatric Oncology, Atatürk University, Faculty of Medicine, Erzurum, Turkey

Ebubekir Bakan

Department of Biochemistry, Atatürk University, Faculty of Medicine, Erzurum, Turkey

Possible preventive effect of dantrolene against the peroxidative damage in rat heart which was induced by the administration of an acute dose of adriamycin (ADR, 20 mg/kg, i.p.) has been examined. Forty-eight hours after ADR administration, biochemical changes including the activities of serum creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) and the levels of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in heart tissue were measured. Pretreatment of rats with dantrolene, given i.p. 30 min prior to ADR injection, substantially reduced the peroxidative damage in the myocardium, and markedly lowered the serum CKMB, LDH and AST. The protective effects obtained by dantrolene administration, however, were not complete and did not reach those of the control group. Dantrolene, at 5 mg/kg, was useful to obtain significant protective effects, while the protector effect of higher dantrolene dosing level (10 mg/kg) was weak or absent. These results suggest that, at least in part, due to antioxidative properties, dantrolene may provide a significant protective effect against acute ADR-induced cardiotoxicity.

Key Words: adriamycin • cardiotoxicity • dantrolene • rat


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H Ucuncu, S Taysi, B Aktan, M E Buyukokuroglu, and M Elmastas
Effect of dantrolene on lipid peroxidation, glutathione and glutathione-dependent enzyme activities in experimental otitis media with effusion in guinea pigs
Human and Experimental Toxicology, November 1, 2005; 24(11): 567 - 571.
[Abstract] [PDF]