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Human & Experimental Toxicology
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Oximes-induced reactivation of rat brain acetylcholinesterase inhibited by VX agent

Kamil Kuca

Purkyne Military Medical Academy, Department of Toxicology, PO Box 35/T, 500 01 Hradec Krá lové, Czech Republic kucakam{at}pmfhk.cz

Jirí Kassa

Purkyne Military Medical Academy, Department of Toxicology, PO Box 35/T, 500 01 Hradec Krá lové, Czech Republic

A comparison of one mono- and seven bisquaternary acetylcholinesterase (AChE) reactivators of acetylcholinesterase inhibited by VX agent was performed. As a source of the acetylcholinesterase, a rat brain homogenate was taken. There were significant differences in reactivation potency of all tested oximes. The oxime TO205 seems to be the most efficacious followed by TO046, HI-6, HS-6, K027, obidoxime, MMC and 2-PAM. In addition, the results of this study showed that the reactivation potency of the tested reactivators depends on many factors-such as the number of pyridinium rings, the number of oxime groups and their position, as well as the length and the shape of linkage bridge between two pyridinium rings.

Key Words: acetylcholinesterase • in vitro • oximes • reactivation • VX

Human & Experimental Toxicology, Vol. 23, No. 4, 167-171 (2004)
DOI: 10.1191/0960327104ht434oa
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This article has been cited by other articles:


Home page
 International Journal of ToxicologyHome page
J. Kassa, D. Jun, and K. Kuca
The Reactivating and Therapeutic Efficacy of Oximes to Counteract Russian VX Poisonings
International Journal of Toxicology, September 1, 2006; 25(5): 397 - 401.
[Abstract] [Full Text] [PDF]


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