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Human & Experimental Toxicology
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Evaluating the cytotoxicity of ionic liquids using human cell line HeLa

P Stepnowski

Faculty of Chemistry, University of Gdansk, PL 80-952 Gdaynsk, ul. Sobieskiego 18, Polandsox{at}chem.univ.gda.pl

A C Skladanowski

A Ludwiczak

Intercollegiate Faculty of Biotechnology, Medical University of Gdansk & University of Gdansk, ul. Debinki 1, 80-211 Gdansk, Poland

E Laczynska

Faculty of Chemistry, University of Gdannsk, PL 80-952 Gdansk, ul. Sobieskiego 18, Poland

This paper presents cytotoxicity data of selected imidazolium ionic liquids evaluated in vitro on the human tumor cell line HeLa. It was found that for 1-n-butyl-3-methylimidazolium entities the toxicity depends strongly on the associated anion; EC50 values are lowest for tetrafluoroborate. No direct dependence of the reduced effect concentration was found on elongating the short, methyl chain to ethyl or n-hexyl. Only for the ionic liquid with an n-decyl chain, the longest one studied, did higher hydrophobicity result in a EC50 one order of magnitude lower than that obtained with the n-butyl entity. The effect concentrations of imidazolium ionic liquids in the HeLa system used are lower than the values obtained for conventional organic solvents such as dichloromethane, toluene or xylene.

Key Words: cytotoxicity • HeLa cell line • ionic liquids • prospective risk assessment

Human & Experimental Toxicology, Vol. 23, No. 11, 513-517 (2004)
DOI: 10.1191/0960327104ht480oa
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