Human & Experimental Toxicology

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pepeljnjak, S
Right arrow Articles by Pavlovic, M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pepeljnjak, S
Right arrow Articles by Pavlovic, M
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Human & Experimental Toxicology, Vol. 23, No. 1, 15-19 (2004)
DOI: 10.1191/0960327104ht409oa

The ability of fungal isolates from human lung aspergilloma to produce mycotoxins

S Pepeljnjak

Department for Microbiology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Schrottova 39, HR-10000 Zagreb, Croatia

Z Slobodnjak

Thoracic Surgery Unit, Chest Clinical Hospital, Jordanovac 104, HR-10000 Zagreb, Croatia

M Segvic

Department for Microbiology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Schrottova 39, HR-10000 Zagreb, Croatia

M Peraica

Institute for Medical Research and Occupational Health, Ksaverska c.2, HR-10000 Zagreb, Croatia

M Pavlovic

Department for Occupational and Environmental Medicine, Institute for Medical Research and Occupational Health, Ksaverska c.2, POB 291, 10000 Zagreb, Croatiampavlov{at}imi.hr

This study included 11 adult patients (seven men and four women) who had been surgically treated for pulmonary aspergilloma in the Republic of Croatia within two years. Mycological analysis was positive for Aspergillus genus in five samples of surgically removed tissue. A. fumigatus was isolated in three and A. versicolor in two samples. Their mycotoxigenic potency was determined by thin layer chromatography. A. fumigatusstrains were found to produce aflatoxin B1 (AFB), and two of them aflatoxin G1. A. versicolor strains produced AFB1 and sterigmatocystin. Neither isolated Aspergillus strain produced aflatoxin G2 or ochratoxin A. Fungal growth and production of mycotoxins are the consequences of interaction of fungus, host and environment. One has also to take into consideration that the production of mycotoxins in vitro does not reflect what these fungi may produce in human organisms.

Key Words: aflatoxins • aspergilloma • Aspergillus fumigatus • Aspergillus versicolor • lung • sterigmatocystin


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
L. Y. Chiang, D. C. Sheppard, F. N. Gravelat, T. F. Patterson, and S. G. Filler
Aspergillus fumigatus Stimulates Leukocyte Adhesion Molecules and Cytokine Production by Endothelial Cells In Vitro and during Invasive Pulmonary Disease
Infect. Immun., August 1, 2008; 76(8): 3429 - 3438.
[Abstract] [Full Text] [PDF]