This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Pajoumand, A. Articles by Shadnia, S. Search for Related Content PubMed PubMed Citation Articles by Pajoumand, A. Articles by Shadnia, S. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB ACETAMINOPHEN ACETYLCYSTEINE Medline Plus Health Information Pain Relievers Social Bookmarking                         What's this?

Successful treatment of acetaminophen overdose associated with hepatic failure

Nasser Jalali

Poison Centre, Loghman–Hakim Hospital, Faculty of Medicine, Shaheed–Beheshti University of Medical Science, Tehran, Iran

Mohammad Abdollahi

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran

Shahin Shadnia

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran, Poison Centre, Loghman–Hakim Hospital, Faculty of Medicine, Shaheed–Beheshti University of Medical Science, Kamali Avenue, South Karegar Street, Tehran–13334, Iran, shahinshadnia{at}hotmail.com

Acetaminophen is the most widely used antipyretic and analgesic drug in the world. Acetaminophen poisoning and the following hepatic failure are not rare and are the most common indications of liver transplantation in the USA and Europe. In this case report, the patient was a 25–year old woman with hepatic failure who was brought to Loghman–Hakim Poison Centre 24 hours after attempted suicide with 100 tablets of acetaminophen, 325 mg. She was treated with N–acetylcysteine (NAC) and discharged from the hospital 12 days after admission and followed up for 1 month. In conclusion, acetaminophen poisoning should be considered in the differential diagnoses of hepatic failure. In acetaminophen–induced hepatic damage the administration of NAC must always be considered even after 24 hours of overdose.

Key Words: acetaminophen overdose • acute poisoning • hepatic failure

Human & Experimental Toxicology, Vol. 22, No. 8, 453-458 (2003)
DOI: 10.1191/0960327103ht325cr


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?