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Human & Experimental Toxicology, Vol. 22, No. 8, 439-443 (2003)
DOI: 10.1191/0960327103ht373oa
© 2003 SAGE Publications

Designation of substances as skin sensitizing chemicals: a commentary

I Kimber

R J Dearman

Syngenta Central Toxicology Laboratory, Alderley Park, Macclestield, Cheshire, UK

G F Gerberick

Miami Valley Laboratories, Procter & Gamble Company,Cincinnati, Ohio, USA

R Roggeband

Procter & Gamble Eurocor, Strombeek–Bever, Belgium

D A Basketter

SEAC, Unilever, Colworth Laboratory, Sharnbrook, Bedfordshire, UK

During the last 10 years there have been several aftempts to define criteria for the integration of experimental and clinical data into schemes that can be used for the designation of chemicals as skin sensitizers (and in some instances respiratory allergens). The last such proposal was made recently in this journal by Schnuch and colleagues (Hum Exp Toxicol 2002; 2: 439–44) who invited critical discussion and debate of the area. In this present article we have sought to build upon and refine further those previous recommendations and suggest here a modified scheme for the classification of chemicals as confirmed or probable skin sensitizers. This new scheme we believe provides a realistic framework within which informed decisions can be reached about likely skin sensitizing activity based upon judicious consideration of clinical and experimental information.

Key Words: allergic contact dermatitis • classification • predictive tests • skin sensitization


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 Hum Exp ToxicolHome page
A Schnuch, H Lessmann, D Becker, T L Diepgen, H Drexler, S Erdmann, M Fartasch, H Greim, P Kricke-Helling, R Merget, et al.
Designation of substances as skin sensitizing chemicals: a reply
Human and Experimental Toxicology, March 1, 2005; 24(3): 157 - 159.
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