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Human & Experimental Toxicology
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The elucidation of epinephrine as an antihypotensive agent in abamectin intoxication

Dur-Zong Hsu

Po-Jung Chiang

Graduate Institute of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan

Ching-Hung Hsu

Department of Public Health, School of Medicine, Taipei Medical College, Taipei, Taiwan

Bu-Miin Huang

Department of Cell Biology and Anatomy, National Cheng Kung University Medical College, Tainan, Taiwan

Jou-Fang Deng

Division of Clinical Toxicology, Department of Medicine, Veterans General Hospital-Taipei, Taipei, Taiwan

Ming-Yie Liu

Graduate Institute of Environmental and Occupational Health, Medical College, National Cheng Kung University, Tainan, Taiwanmyliu{at}mail.ncku.edu.tw

Abamectin (ABM) has been used in some suicidal attempt cases in recent years. ABM-intoxicated patients demonstrate low mean arterial pressure (MAP) and commonly treated with catecholamine to burst MAPs in their intensive cares. This investigation examined roles of epinephrine on MAP, heart rate (HR), and therein baroreflex sensitivity (BRS-HR/MAP) during ABM intoxication in rats. Oral application of ABM (20 mg/kg) induced an increase in HR and BRS accompanied by a decrease in MAP. These effects, except for on BRS, were abolished by concomitant epinephrine injection [100 mg/ kg, subcutaneously (s.c.)]. ABM also induced an increase in serum nitric oxide levels, which was partly antagonized by epinephrine. In summary, oral application of ABM induced a decrease in MAP. Administration of epinephrine sustained the normal range of MAP via nitric oxide regulation, but it has no effect on BRS due to the synchronous changes of MAP and HR in ABMintoxicated rats.

Key Words: abamectin • baroreflex sensitivity • epinephrine • heart rate • mean arterial pressure • nitric oxide

Human & Experimental Toxicology, Vol. 22, No. 8, 433-437 (2003)
DOI: 10.1191/0960327103ht378oa
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