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Does hepatomegaly alter iron-dependent oxidative effects in human plasma?

Physical Chemistry-PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina

Abraham Lemberg

Physiopathology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina

Susana Puntarulo

Physical Chemistry-PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina

A four-fold increase in the iron content of normal subjects was detected in plasma after 5 hours of iron administration. Iron supplementation had a surprisingly erratic effect on four patients with hepatomegaly secondary to heart insufficiency, since the increase in the iron content in the plasma after iron-dextran administration was either within the control range or significantly lower, independently of the initial values. Thiobarbituric acid reactive substances (TBARS) content was 2.5±0.2 and 4.39±0.4 µM for control and hepatomegalic subjects, respectively. The TBARS basal level was increased by iron supplementation. The difference between TBARS content in hepatomegalic and control subjects, after 5 hours of iron administration, was increased by 50% as compared to the difference in the basal content of TBARS. -Tocopherol (-T) content in plasma from subjects with hepatomegaly showed a significant decrease (—-41%) as compared to control subjects. No significant difference over the basal level of -T was measured after 5 hours of iron administration in any subject. The data presented here suggest that abnormal liver condition affects iron-dependent oxidative stress in plasma. Moreover, -T does not seem to be the main antioxidant to control iron-dependent oxidative stress in plasma.

Key Words: hepatomegaly • human plasma • iron overload • oxidative damage

Human & Experimental Toxicology, Vol. 22, No. 7, 401-405 (2003)
DOI: 10.1191/0960327103ht372oa


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