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Human & Experimental Toxicology
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Effect of Ochratoxin a on human haematopoietic progenitors proliferation and differentiation: an in vitro study

R Froquet

Laboratoire de Microbiologie et Sécurité Alimentaire, Ecole Supérieure de Microbiologie et SécuritéAlimentaire de Brest, ISAMOR, Technopôle Brest-Iroise, 29280 Plouzané, France

G Le Dréan

Laboratoire de Microbiologie et Sécurité Alimentaire, Ecole Supérieure de Microbiologie et SécuritéAlimentaire de Brest, ISAMOR, Technopôle Brest-Iroise, 29280 Plouzané, France

D Parent-Massin

Laboratoire de Microbiologie et Sécurité Alimentaire, Ecole Supérieure de Microbiologie et SécuritéAlimentaire de Brest, ISAMOR, Technopôle Brest-Iroise, 29280 Plouzané, France

Ochratoxin A (OTA) is a mycotoxin food and feedcontaminant known to induce nephro and hepatotoxicity in human and animal, and related to human Balkan Endemic Nephropathy. However, haematological troubles are also observed in case of acute OTA intoxication. These disorders observed in animals emphasise the necessity to determine if OTA exposure induce damage to haematopoietic system in human. The effect on haematopoiesis has been evaluated usingin vitro clonogenic assays of the three lineages i.e., platelet, red and white blood cell progenitors. Human erythroblastic and granulomonocytic progenitor proliferation is decreased in the presence of 102 mM OTA. Platelet progenitors were destroyed at 102 mM OTA. For the lowest concentrations haematopoietic progenitor proliferation is not affected by OTA. Comparison with other mycotoxins known to be myelotoxic shows that OTA is less myelotoxic than trichothecenes.

Key Words: haematopoietic progenitors • human • ochratoxin A • myelotoxicity

Human & Experimental Toxicology, Vol. 22, No. 7, 393-400 (2003)
DOI: 10.1191/0960327103ht375oa
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