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Human & Experimental Toxicology, Vol. 22, No. 6, 315-317 (2003)
DOI: 10.1191/0960327103ht368oa

Radiation-induced versus endogenous DNA damage: commentary on Pollycove and Feinendegen

Hiroshi Tanooka

National Institute of Radiological Sciences

Quantitative comparison of ROS-induced endogenous DNA damage with DNA damage induced by ionizing radiation at environmental level, presented by Pollycove and Feinedegen, is timely and provides basic data for establishing a a sound rule for radiation protection. Main point added to their estimation is quantitative data on oxidative damage to DNA precursormolecules, such as oxo dGTP and their cellular decomposition efficiency. If the precursor damages are taken into account, the amount of initial endogenous DNA damage would be increased by a factor of 100 / 10 000

Key Words: commentary • endogenous DNA damage • radiation • reactive oxygen species


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