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Protective role of DLa-lipoic acid against adriamycin-induced cardiac lipid peroxidation

K P Malarkodi

Department of Medical Biochemistry, University of Madras, Chennai, India

P Varalakshmi

Department of Medical Bio-chemistry, PGIBMS, University of Madras, Taramani Campus, Chennai, India 600 113 drvlakshmi{at}yahoo.com

The cytoprotective activity of a-lipoic acid against free radical toxicity manifested during adriamycin (ADR)induced cardiotoxicity has been investigated. ADR is a potent antitumour drug known to cause severe cardiotoxicity. Although ADR generates free radicals, the role of these radicals in the development of cardiac toxicity is still not well understood. In the present study, we evaluated the influence of chronic ADR treatment on the cellular defence mechanism against free radicals and the effect of a-lipoic acid supplementation on ADR-induced cardiotoxicity in male Wistar rats. The increase in lipid peroxidation (LPO) and activities of serum myocardial enzymes, namely lactate dehydrogenase (LDH) and creatinephosphokinase, associated with the decrease in activities of enzymatic (SOD, CAT, GPx, G6PD and GR) and non-enzymatic (GSH, Vit C and Vit E) antioxidants levels were the salient features observed in ADR-induced cardiotoxicity. Lipoic acid pretreated groups showed significant increase in activities of both enzymatic and non-enzymatic antioxidant levels. These observations highlight the antioxidant property ofa-lipoic acid and its cytoprotective action against ADR-induced cardiotoxicity.

Key Words: adriamycin • cardiotoxicity • lipid peroxidation • lipoic acid

Human & Experimental Toxicology, Vol. 22, No. 5, 249-254 (2003)
DOI: 10.1191/0960327103ht358oa


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