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Human & Experimental Toxicology
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Acute lead exposure induces renal haeme oxygenase-1 and decreases urinary Na excretion

Hilda Vargas

Department of Molecular Biomedicine, Centro de Investigació n y de Estudios Avanzados del IPN, Avenida Instituto Politécnico Nacional 2508, México, D.F., CP 07300, México; bescalan{at}mail.cinvestav.mx; Escuela Superior de Medicina Instituto Politécnico Nacional México D.F., México

Carlos Castillo

Escuela Superior de Medicina Instituto Politécnico Nacional México D.F., México

Francisco Posadas

Department of Pharmacology, Centro de Investigación y de Estudios Avanzados del IPN, México

Bruno Escalante

Department of Molecular Biomedicine, Centro de Investigación y de Estudios Avanzados del IPN. México

The effects of acute lead exposure on renal function, lipid peroxidation and the expression of haeme oxygenase (HO) in rat kidney were determined. A single injection of lead acetate (50 mg Pb/kg) was given to rats. Changes in renal function, characterized by a significant reduction in the Na excretion was observed six hours after Pb exposure; this effect persisted for 24 hours. TBARS levels increased in kidney cortex 24 hours after Pb administration. In kidney cortex, Pb exposure affected the expression of HO-1, a renal protein associated with oxidative stress. HO-1 mRNA increased 2.3-fold, three hours after Pb administration and remained increased for six, 12 and 24 hours. HO enzymatic activity and HO-1 protein increased six and three hours after Pb administration, respectively, and remained increased at 24 hours. HO inhibition by tin-protoporphyrin, potentiated Pb-induced increase in TBARS and prevented the Pb-induced reduction in Na excretion. Our data suggest that Pb may be acting through the generation of oxidant products and induction of HO.

Key Words: haeme oxygenase-1 • lead acetate • lipid peroxidation

Human & Experimental Toxicology, Vol. 22, No. 5, 237-244 (2003)
DOI: 10.1191/0960327103ht360oa
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This article has been cited by other articles:


Home page
 Hum Exp ToxicolHome page
S. Kasperczyk, E. Birkner, A. Kasperczyk, and J. Kasperczyk
Lipids, lipid peroxidation and 7-ketocholesterol in workers exposed to lead
Human and Experimental Toxicology, June 1, 2005; 24(6): 287 - 295.
[Abstract] [PDF]


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