This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Akdogan, M. Articles by Delibas, N. Search for Related Content PubMed PubMed Citation Articles by Akdogan, M. Articles by Delibas, N. Social Bookmarking                         What's this?

Investigation of biochemical and histopathological effects of Mentha piperita L. and Mentha spicata L. on kidney tissue in rats

Suleyman Demirel University, Faculty of Medicine, Department of Biochemistry and Clinical Biochemistry, Isparta, Turkey; Suleyman Demirel University, School of Medicine, Department of Biochemistry and Clinical Biochemistry, 32040 Isparta, Turkey; akdogan2000{at}hotmail.com

Ibrahim KWlWnc

Suleyman Demirel University, Faculty of Medicine, Department of Biochemistry and Clinical Biochemistry, Isparta, Turkey

Meral Oncu

Erdal Karaoz

Suleyman Demirel University, Faculty of Medicine, Department of Histology and Embryology, Isparta, Turkey

NamWk Delibas

Suleyman Demirel University, Faculty of Medicine, Department of Biochemistry and Clinical Biochemistry, Isparta, Turkey

Peppermint plants have been used as a herbal medicine for many conditions, including loss of appetite, common cold, bronchitis, sinusitis, fever, nausea, vomiting and indigestion. This study is aimed at investigating the biochemical and histological effects of Mentha piperita L., growing in the Yenisar Bademli town of Isparta City, and Mentha spicata L., growing on the Anamas high plateau of Isparta City, on rat kidney tissue. Forty-eight male Wistar albino rats weighing 200 ^/ 250 g were used for this study. Animals were divided into four experimental groups, each with 12 rats, as follows: control group (group I); 20 g/L M. piperita tea (group II); 20 g/L M. spicata tea (group III); 40 g/L M. spicata tea (group IV). The control group rats were given commercial drinking water (Hayat DANONESA water). The tea for the other groups was prepared daily and provided at all times to the rats during 30 days as drinking water. Plasma urea and creatinine levels were determined, and the levels of thiobarbituric acid reactive substance (TBARS) and the activities of glutathione peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD) were studied in the homogenates of kidney tissue. The levels of plasma urea and creatinine were increased significantly (P B-0.0033) in groups III and IV when compared with group I. The activities of SOD and GSHPx were decreased significantly (P B-0.0033) in group IV when compared with group I. The activities of CAT were decreased significantly in groups III and IV (P B-0.033,P B-0.0033, respectively) when compared with group I. TBARS levels were increased significantly (P B-0.0033) in groups III and IV when compared with group I. In groups II, III and IV, hydropic degeneration of tubular epithelial cells, the epithelial cells with picnotic nuclei and eosinophilic cytoplasm, tubular dilatation and enlargements in Bowman capsules were observed histologically. However, in group II histopathological changes were more slight than in groups III and IV. In group IV, in addition to these changes, extremely hydropic degeneration of tubular epithelial cells, some atrophic tubules and glomerules, and focal mononuclear cell infiltrations in the kidney tissues of the rats were observed. In conclusion, the results indicate that M. piperita does not show nephrotoxicity but M. spicata presents markedly nephrotoxic changes in rats.

Key Words: antioxidant enzymes • kidney toxicity • Mentha piperita • Mentha spicata

Human & Experimental Toxicology, Vol. 22, No. 4, 213-219 (2003)
DOI: 10.1191/0960327103ht332oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M. Guney, B. Oral, N. Karahanli, T. Mungan, and M. Akdogan The effect of Mentha spicata Labiatae on uterine tissue in rats Toxicology and Industrial Health, September 1, 2006; 22(8): 343 - 348. [Abstract] [PDF]

				M Akdogan, M Ozguner, G Aydin, and O Gokalp Investigation of biochemical and histopathological effects of Mentha piperitaLabiatae and Mentha spicata Labiatae on liver tissue in rats Human and Experimental Toxicology, January 1, 2004; 23(1): 21 - 28. [Abstract] [PDF]