SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Human & Experimental Toxicology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Akhgari, M.
Right arrow Articles by Sabzevari, O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Akhgari, M.
Right arrow Articles by Sabzevari, O.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Biochemical evidence for free radicalinduced lipid peroxidation as a mechanism for subchronic toxicity of malathion in blood and liver of rats

Maryam Akhgari

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Mohammad Abdollahi

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 141555-6451, Iran; mohammad.abdollahi{at}utoronto.ca

Abbas Kebryaeezadeh

Ruhollah Hosseini

Omid Sabzevari

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Organophosphorus compounds may induce oxidative stress leading to generation of free radicals and alterations in antioxidant and scavengers of oxygen free radicals (OFRs). The effect of subchronic exposure to malathion in the production of oxidative stress was evaluated in male Wistar rats. Administration of malathion (100, 316, 1000, 1500 ppm) for 4 weeks increased catalase (CAT), superoxide dismutase (SOD) activities as well as malondialdehyde (MDA) concentration in red blood cells (RBC) and liver. However, acetylcholinesterase (AChE) and cholinesterase (ChE) activities were decreased in these samples. The increase in RBC and liver lipid peroxidation correlated well with the inhibition in RBC AChE and liver ChE activities. Elevation of MDA concentrations and increased activities of CAT and SOD showed significant correlations in both RBC and liver samples when different doses of malathion were used. The results of the present study suggest the usefulness of RBC AChE measurement as a good biomarker in the estimation of malathion-induced oxidative stress affecting blood and liver.

Key Words: acetylcholinesterase • catalase • lipid peroxidation • malathion • oxidative stress • superoxide dismutase

Human & Experimental Toxicology, Vol. 22, No. 4, 205-211 (2003)
DOI: 10.1191/0960327103ht346oa
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Hum Exp ToxicolHome page
S. Mansour and A. Mossa
Adverse effects of lactational exposure to chlorpyrifos in suckling rats
Human and Experimental Toxicology, February 1, 2010; 29(2): 77 - 92.
[Abstract] [PDF]

Home page
 Hum Exp ToxicolHome page
K Soltaninejad, S Shadnia, M Afkhami-Taghipour, R Saljooghi, A Mohammadirad, and M Abdollahi
Blood {beta}-glucuronidase as a suitable biomarker at acute exposure of severe organophosphorus poisoning in human
Human and Experimental Toxicology, December 1, 2007; 26(12): 963 - 966.
[Abstract] [PDF]

Home page
 Am J EpidemiolHome page
M. R. Bonner, J. Coble, A. Blair, L. E. Beane Freeman, J. A. Hoppin, D. P. Sandler, and M. C. R. Alavanja
Malathion Exposure and the Incidence of Cancer in the Agricultural Health Study
Am. J. Epidemiol., November 1, 2007; 166(9): 1023 - 1034.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
P. S. Brocardo, F. Assini, J. L. Franco, P. Pandolfo, Y. M.R. Muller, R. N. Takahashi, A. L. Dafre, and A. L. S. Rodrigues
Zinc Attenuates Malathion-Induced Depressant-like Behavior and Confers Neuroprotection in the Rat Brain
Toxicol. Sci., May 1, 2007; 97(1): 140 - 148.
[Abstract] [Full Text] [PDF]

Home page
 Hum Exp ToxicolHome page
F. Teimouri, N. Amirkabirian, H. Esmaily, A. Mohammadirad, A. Aliahmadi, and M. Abdollahi
Alteration of hepatic cells glucose metabolism as a non-cholinergic detoxication mechanism in counteracting diazinon-induced oxidative stress
Human and Experimental Toxicology, December 1, 2006; 25(12): 697 - 703.
[Abstract] [PDF]

Home page
 Hum Exp ToxicolHome page
R. Rahimi, S. Nikfar, and M. Abdollahi
Increased morbidity and mortality in acute human organophosphate-poisoned patients treated by oximes: a meta-analysis of clinical trials
Human and Experimental Toxicology, March 1, 2006; 25(3): 157 - 162.
[Abstract] [PDF]

Home page
 Hum Exp ToxicolHome page
S. Shadnia, E. Azizi, R. Hosseini, S. Khoei, S. Fouladdel, A. Pajoumand, N. Jalali, and M. Abdollahi
Evaluation of oxidative stress and genotoxicity in organophosphorus insecticide formulators
Human and Experimental Toxicology, September 1, 2005; 24(9): 439 - 445.
[Abstract] [PDF]


Advertisement