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A comparative study on the gastroduodenal tolerance of different antianaemic preparations

Department of Pathology and Toxicology, Universidad de Navarra, 31080 Pamplona, Spain maidoate{at}unav.es

A G Gil

A Azqueta

Experimental and Preclinical Toxicology Laboratory, Applied Pharmacobiology Research Centre (CIFA), University of Navarra, Pamplona, Spain

M P Coronel

M Gimeno

Scientific Department, Tedec-Meiji, Farma S.A., Alcalá da Henares, Madrid, Spain

The most significant adverse effect of repeated oral administration of iron-containing antianaemic preparations is the gastroduodenal toxicity, attributable to a direct toxic effect of iron on the glandular epithelium. To assess gastroduodenal mucosal damage and the potential protective effect of different antianaemic preparations, a study was carried out to compare the gastroduodenal toxicity caused by three different types of antianaemic drugs in normal and anaemic rats administered at repeated therapeutic doses. Histological damage to the gastroduodenal mucosa was evaluated using light and electron microscopy. In both normal and anaemic rats, pathological changes were less marked in animals treated with ferrimannitol-ovoalbumin (TM/ FMOA) than in those treated with iron protein succinylate or ferrous sulphate. Electron microscopic studies of duodenal mucosa in normal rats treated with iron protein succinylate and ferrous sulphate confirmed a severe ultrastructural alteration, whereas no changes were detected in animals treated with TM/FMOA. In anaemic rats, slight duodenal ultrastructural changes were noted with all three types of treatment. The effectiveness of the preparations in resolving the anaemia was similar in the three groups. It was concluded that TM/FMOA exerts a protective effect against the toxicity normally observed of the iron in other formulations in normal and anaemic rats, which was attributed to the fact that administration of iron bound to a protein core allows for gradual release of iron.

Key Words: antianaemic preparations • electron microscopy • gastroduodenal mucosa • iron • toxicity

Human & Experimental Toxicology, Vol. 22, No. 3, 137-141 (2003)
DOI: 10.1191/0960327103ht330oa


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