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Ochratoxin a and human chronic nephropathy in Tunisia: is the situation endemic?

Wafa Hassen

Laboratoire de Recherche sur les Substances Biologiquement Compatibles (LRSBC), Faculté de Médecine Dentaire, Rue Avicenne, 5019 Monastir, Tunisia

Abdellatif Achour

Laboratoire de Recherche sur les Substances Biologiquement Compatibles (LRSBC), Faculté de Médecine Dentaire, Rue Avicenne, 5019 Monastir, Tunisia; Service de Néphrologie, CHU, Monastir, Tunisia

Habib Skhiri

Service de Néphrologie, CHU, Monastir, Tunisia

Khira Maaroufi

Faculté de Pharmacie, Rue Avicenne, 5019 Monastir, Tunisia

Farielle Ellouz

Faculté de Pharmacie, Rue Avicenne, 5019 Monastir, Tunisia; Laboratoire de Recherche sur les Substances Biologiquement Compatibles (LRSBC), Faculté de Médecine Dentaire, Rue Avicenne, 5019 Monastir, Tunisia

Edmond Creppy

Laboratoire de Toxicologie et d'Hygiéne Appliquée, UFR des Sciences Pharmaceutiques, Université Bordeaux II, 146 Rue Léo Saignat, 33076 Bordeaux Cedex, France

Hassen Bacha

Laboratoire de Recherche sur les Substances Biologiquement Compatibles (LRSBC), Faculté de Médecine Dentaire, Rue Avicenne, 5019 Monastir, Tunisia hassen.bacha{at}fmdm.rnu.tn

Ochratoxin A (OTA) is a nephrotoxic mycotoxin that is being increasingly considered as the main causal agent of Balkan endemic nephropathy (BEN), a fatal kidney disease associated with the end stage of urothelial tumours. However, despite the considerable amount of data, it is still controversial whether OTA plays a causative or only a subordinate role in the induction of this human nephropathy. Tunisia for years had to confront a very similar human nephropathy, which is tentatively called chronic interstitial nephropathy of unknown cause. This study tends firstly to consolidate the suspected link between this Tunisian chronic interstitial nephropathy (CIN) of unknown cause and the presence of OTA in the blood and food of such patients, and second to enlighten the endemic character of this particular nephropathy. Therefore, in four consecutive inquiries, performed within the period 1991-2000, blood and food OTA contaminations were assayed and compared for 954 nephropathy patients and 205 healthy subjects from the Tunisian general population. This survey was also designed to show that, although the whole population is likely to be exposed to OTA, specific people living in conditions showing similarities with the Balkans do have a kidney disease apparently linked to ochratoxin in food. The results showed that the highest incidences were found in patients with CIN of unknown cause. Indeed, the percentages of OTA-positive samples ranged from 93% to 100%, whereas it was only from 62% to 82% in healthy subjects. Mean OTA concentrations were also higher in patients with CIN of unknown cause than in controls (44.4±-19 mg/L to 55.6±-19 mg/L as opposed to 1.22±-1.2 mg/L to 3.35±-2.32 mg/L, respectively). This study emphasizes further the implication of OTA on this particular human nephropathy and underlines the probable causative role of OTA in the onset of this disease. It is important to note that the highest levels of food OTA contamination were found in the group presenting with CIN of unknown cause, indicating that, similar to the case in the Balkans, people are exposed to OTA essentially by their food.

Key Words: ochratoxin A • ochratoxicosis in humans in Tunisia

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