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Human & Experimental Toxicology, Vol. 22, No. 12, 653-658 (2003)
DOI: 10.1191/0960327103ht411oa

Protective effect of curcumin against lead neurotoxicity in rat

Pradeep K Shukla

Vinay K Khanna

Industrial Toxicology Research Centre, PO Box 80, MG Marg, Lucknow 226001, India

Mohd Y Khan

Dr RML Avadh University, Faizabad 224001, India

Rikhab C Srimal

Industrial Toxicology Research Centre, PO Box 80, MG Marg, Lucknow 226001, India rcsrimal{at}yahoo.com

Curcumin (diferuloylmethane), an active ingredient of turmeric, is known to have multiple activities, including an antioxidant property, and has been suggested to be of use in treatment of several diseases. The present study has been undertaken to investigate the protective effect of curcumin against lead-induced neurotoxicity in rats. Exposure of rats to lead (50 mg/kg po) for 45 days caused an increase in lipid peroxidation (LPO) and a decrease in reduced glutathione (GSH) levels in cerebellum, corpus striatum, hippocampus and frontal cortex as compared with controls. Lead levels were significantly increased in these rats. Activity of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) decreased in all the brain regions following lead exposure. Interestingly, cotreatment with curcumin (100 mg/kg po) and lead (50 mg/kg po) for 45 days caused a significant decrease in LPO with concomitant decrease in lead levels in all the brain regions as compared with those treated with lead alone. A significant increase in reduced glutathione (GSH) levels, SOD and CAT activities was also observed in all the four brain regions in rats simultaneously treated with curcumin and lead. The results suggest that curcumin may prevent lead-induced neurotoxicity.

Key Words: brain • curcumin • lead • neuroprotection • oxidative stress


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S. Kasperczyk, E. Birkner, A. Kasperczyk, and J. Kasperczyk
Lipids, lipid peroxidation and 7-ketocholesterol in workers exposed to lead
Human and Experimental Toxicology, June 1, 2005; 24(6): 287 - 295.
[Abstract] [PDF]