This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Sinha, C. Articles by Shukla, G. S Search for Related Content PubMed PubMed Citation Articles by Sinha, C. Articles by Shukla, G. S Social Bookmarking                         What's this?

Species variation in pesticide-induced blood-brain barrier dysfunction

Predictive Toxicology Research Group, Industrial Toxicology Research Centre, Lucknow, India

Girja S Shukla

Surgery Department, University of Vermont, College of Medicine, E303 Given Bldg., Burlington, VT 05405, USA Girja.Shukla{at}uvm.edu

Neurological disorders following acute or chronic exposure to pesticides have been reported in a number of human cases. However, the mechanism(s) by which pesticides produce central nervous system dysfunction is not clear. The objective of the present study was to examine the functional status of blood-brain barrier (BBB) in rats and mice exposed to selected pesticides of different chemical groups. Adult male albino rats and mice were exposed (1/10 of LD₅₀) daily to dichlorvos (organophosphate), lindane (organochlorine) and carbofuran (carbamate) through oral intubation for 3 days. The status of BBB was evaluated by determining brain sodium fluorescein dye uptake and brain uptake index (BUI) in relation to serum dye level. The brain dye uptake and BUI in pesticide-exposed rats did not differ significantly in comparison to that of controls. However, brain dye uptake and BUI were increased significantly in mice exposed to dichlorvos (85%, 40%), lindane (79%, 26%) and carbofuran (129%, 61%). The results of this study show that mouse BBB system is more sensitive to pesticide-induced breach as compared to that of rat. These variations may have a role in determining the outcome of pesticide neurotoxicity in different species.

Key Words: blood-brain barrier • carbofuran • dichlorvos • lindane • neurotoxicity • species difference

Human & Experimental Toxicology, Vol. 22, No. 12, 647-652 (2003)
DOI: 10.1191/0960327103ht405oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J Gomes, O. Lloyd, and Z Hong Oral exposure of male and female mice to formulations of organophosphorous pesticides: congenital malformations Human and Experimental Toxicology, March 1, 2008; 27(3): 231 - 240. [Abstract] [PDF]