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Hepatocurative and antioxidant profile of HP-1, a polyherbal phytomedicine

K Singh

S Sethi

S C Sharma

K L Bedi

J Singh

B S Jaggi

Biochemistry Lab, Division of Pharmacology, Regional Research Laboratory, Canal Road, Jammu-Tawi 180 001, India

R K Johri

Biochemistry Lab, Division of Pharmacology, Regional Research Laboratory, Canal Road, Jammu-Tawi 180 001, Indiarakeshkjohri{at}rediffmail.com

HP-1 a herbal formulation comprising of Phyllanthus niruri and extracts of Terminalia belerica, Terminalia chebula, Phyllanthus emblica and Tinospora cordifoliahas been evaluated for hepatoprotective activity against carbon tetrachloride (CCl₄) induced toxicity. Results show that HP-1 reversed the leakage of lactate dehydrogenase (LDH) and glutamate pyruvate transaminase (GPT) and prevented the depletion of glutathione (GSH) levels in a primary monolayer culture of rat hepatocytes (in vitro). HP-1 attenuated the serum toxicity as manifested in elevated levels of transaminases (glutamate oxaloacetate transaminase (GOT), and GPT) The anti-oxidative enzymes in liver (catalase and superoxide dismutase (SOD)) were restored to normal values after the oral administration of HP-1. HP-1 suppressed the formation of the superoxide anion radical and reduced CCl₄ mediated lipid peroxidation (LPO). Silymarin and antioxidants (ascorbic acid,ß-carotene and tocopherol) were used for comparison. The present study showed that HP-1 is a potential hepatoprotective formulation with an additional attribute of being anti-peroxidative.

Key Words: antioxidant • hepatoprotective • Phyllanthus niruri • Phyllanthus emblica • Terminalia belerica • Terminalia chebula • Tinospora cordifolia

Human & Experimental Toxicology, Vol. 22, No. 12, 639-645 (2003)
DOI: 10.1191/0960327103ht406oa


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