SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Human & Experimental Toxicology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Holladay, S D
Right arrow Articles by Blaylock, B L
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Holladay, S D
Right arrow Articles by Blaylock, B L
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

The mouse as a model for developmental immunotoxicology

S D Holladay

Department of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, Virginia 24061-0442, USA; holladay{at}vt.edu

B L Blaylock

College of Pharmacy and Health Sciences, University of Louisiana at Monroe, Monroe, Louisiana, USA

The laboratory mouse has been the most extensively used model system for demonstrating postnatal immune deficits following perinatal immunotoxicant exposure. Assays utilized have historically been those developed for adult mice. Clear gaps in the available database exist, however, regarding the predictive strength of adult mouse immune screens for detecting either transient or long-lasting postnatal immune suppression. Limited information is also available regarding postnatal ages when various immune assays can be first employed to detect developmental immunotoxicity in mice. Furthermore, difficulties and expense inherent with breeding of in-bred mice, as used for adult immunotoxicity studies, raise questions regarding the feasibility of an in-bred mouse model as a standard, widely available developmental immunotoxicity testing system. These and additional concerns will need to be addressed as a model system with utility for studying developmental immunotoxicants is produced.

Key Words: developmental immmunotoxicology • model development • mouse • risk assessment

Human & Experimental Toxicology, Vol. 21, No. 9-10, 525-531 (2002)
DOI: 10.1191/0960327102ht292oa
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 International Journal of ToxicologyHome page
L. A. Burns-Naas, K. L. Hastings, G. S. Ladics, S. L. Makris, G. A. Parker, and M. P. Holsapple
What's So Special about the Developing Immune System?
International Journal of Toxicology, March 1, 2008; 27(2): 223 - 254.
[Abstract] [Full Text] [PDF]


Advertisement