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Human & Experimental Toxicology, Vol. 21, No. 9-10, 521-523 (2002)
DOI: 10.1191/0960327102ht291oa

The use of the rat in developmental immunotoxicology studies

R E Chapin

Pfizer Global R&D, Drug Safety Evaluation, Eastern Point Rd., MS 8274-1336, Groton, Connecticut 06340, USA; robert_e_chapin{at}groton.pfizer.com

The benefits and costs are discussed for the possibility of using pups generated in breeding studies for additional assessments, such as evaluating immunotoxicity. Such an approach is logistically challenging, but not overwhel ming.

Key Words: developmental immunotoxicology • reproductive toxicology


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