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Critical windows in development of the rodent immune system

Department of Microbiology, Immunology, and Cell Biology and the Mary Babb Randolph Cancer Center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia 26505, USA; Mary Babb Randolph Cancer Center, P.O. Box 9300, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia 26505, USA; klandreth{at}wvu.edu

The immune system of rodents, like that in humans, develops from a population of pluripotential hematopoietic stem cells (HSC) that are generated early in gestation from uncommitted mesenchymal stem cells in the intra-embryonic splanchnoplure surrounding the heart. This early population of HSC gives rise to all circulating blood cell lineages, including cells of the innate and acquired immune system. To access the impact of chemical exposure on the developing immune system and establish developmental windows of potential vulnerability to these exposures, it is essential to first consider the anatomical development of hematopoietic and lymphopoietic tissues and the sequence of appearance of cells that give rise to the immune system. This is particularly true in embryonic development because, after they initially appear in intra-embryonic mesenchyme early in gestation, HSC migrate through an orderly series of tissues before establishing residence in the bone marrow and thymus. The effect of exposure to chemical insults in utero, then, may differ depending on the specific timing of exposure and anatomical location of hematopoiesis. Mechanisms and consequences of developmental immunotoxicity in experimental animals will need to be considered in that context. This review presents an overview of developmental hematopoiesis and a working hypothesis of critical developmental windows of vulnerability of this developmental system to toxic insult by chemical exposure.

Key Words: critical windows • embryogenesis • hematopoiesis • immunity

Human & Experimental Toxicology, Vol. 21, No. 9-10, 493-498 (2002)
DOI: 10.1191/0960327102ht287oa


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