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Venlafaxine poisoning complicated by a late rise in creatine kinase: two case reports

Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK; james.oliver{at}ed.ac.uk

C Kelly

Scottish Poisons Information Bureau, NPIS Edinburgh, Royal Infirmary, Edinburgh EH3 9YW, UK

D Jarvie

Clinical Biochemistry, Royal Infirmary, Edinburgh EH3 9YW, UK

S Denieul

Lothian and Borders Forensic Science Laboratory, 11 Howdenhall Road, Edinburgh EH16 6TF, UK

D N Bateman

Scottish Poisons Information Bureau, NPIS Edinburgh, Royal Infirmary, Edinburgh EH3 9YW, UK

Newer anti-depressants are often considered to be safer than more established anti-depressants. However, clinical experience of the effects of these agents in overdose is limited. Here, we present two cases of venlafaxine overdose that were complicated by a delayed rise in plasma creatine kinase. Although the clinical consequences were not serious, physicians should be alerted to the possibility of delayed rhabdomyolysis or serotonin syndrome in patients who have taken venlafaxine in overdose.

Key Words: anti-depressant • creatine kinase • overdose • venlafaxine

Human & Experimental Toxicology, Vol. 21, No. 8, 463-466 (2002)
DOI: 10.1191/0960327102ht274cr


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