Human & Experimental Toxicology

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Register here to gain access to SAGE's 500+ Journals Online

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tugwood, J D
Right arrow Articles by Montague, C T
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tugwood, J D
Right arrow Articles by Montague, C T
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Human & Experimental Toxicology, Vol. 21, No. 8, 429-437 (2002)
DOI: 10.1191/0960327102ht282oa

Biology and toxicology of PPARg ligands

J D Tugwood

AstraZeneca Pharmaceuticals Safety Assessment Group, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK; jonathan.tugwood{at}astrazenica.com

C T Montague

Medical Research Council, Diabetes Research Group, PO Box 19070, Tygerberg, 7505 Cape Town, South Africa

The peroxisome proliferator activated receptor-gamma (PPARg) is an attractive target for therapeutic intervention, as modulation of PPARg-regulated pathways is potentially beneficial in a number of disease areas. This review provides an overview of what is known about the biology of PPARg, and an indication of what progress has been made towards drug development in several therapy areas. As well as efficacy, the safety of drugs is of course an important issue, and a substantial volume of preclinical and clinical information has already accumulated for PPARg agonists. Here we discuss some of the major toxicology issues with PPARg agonists, and give a perspective on likely issues concerning the development of PPARgmodulators in the future.

Key Words: PPARgamma • thiazolidinediones • Type II diabetes


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Journal of Pharmacy PracticeHome page
P. Lada and U. Idrees
Toxicity of Oral Agents Used to Treat Diabetes
Journal of Pharmacy Practice, June 1, 2005; 18(3): 145 - 156.
[Abstract] [PDF]

Home page
 J. Lipid Res.Home page
S. L. M. Coort, W. A. Coumans, A. Bonen, G. J. van der Vusse, J. F. C. Glatz, and J. J. F. P. Luiken
Divergent effects of rosiglitazone on protein-mediated fatty acid uptake in adipose and in muscle tissues of Zucker rats
J. Lipid Res., June 1, 2005; 46(6): 1295 - 1302.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
S. Ekins, E. Kirillov, E. A. Rakhmatulin, and T. Nikolskaya
A NOVEL METHOD FOR VISUALIZING NUCLEAR HORMONE RECEPTOR NETWORKS RELEVANT TO DRUG METABOLISM
Drug Metab. Dispos., March 1, 2005; 33(3): 474 - 481.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z.-Z. Shan, K. Masuko-Hongo, S.-M. Dai, H. Nakamura, T. Kato, and K. Nishioka
A Potential Role of 15-Deoxy-{Delta}12,14-prostaglandin J2 for Induction of Human Articular Chondrocyte Apoptosis in Arthritis
J. Biol. Chem., September 3, 2004; 279(36): 37939 - 37950.
[Abstract] [Full Text] [PDF]