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Comments on the Jayjock et al. paper

Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas, Kansas City, Kansas 66160-7417, USA; Section of Environmental Toxicology, GSF-Institut für Toxikologie, Neuherberg, Germany; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA; krozman{at}kumc.edu

J Doull

Section of Environmental Toxicology, GSF-Institut für Toxikologie, Neuherberg, Germany

Establishing hormesis as an evolution-based biological phenomenon requires a broad discussion of its implications for currently used risk paradigms. The Jayjock et al.papers provide an industrial hygienist’s perspective and, as such, represent a valuable contribution to this discussion. Our comments outline a toxicologist’s view on the limits and practicability of the Jayjock et al. suggestions.

The arguments are primarily based on the shape of dose and time responses and associated variabilities and uncertainties. Human & Experimental Toxicology (2002) 21,405–406.

Key Words: hormesis • occupational exposure limits (OELs) • threshold limit values (TLVs)

Human & Experimental Toxicology, Vol. 21, No. 7, 405-406 (2002)
DOI: 10.1191/0960327102ht270xx


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