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Human & Experimental Toxicology
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Effects of occupational exposure to styrene on expression of adhesion molecule on leukocytes

E Jahnová

Institute of Preventive and Clinical Medicine, Limbová 14, 833 01 Bratislava, Slovak Republic; jahnova{at}upkm.sk

J Tulinská

S Weissová

M Dusinská

Institute of Preventive and Clinical Medicine, Limbová 14, 833 01 Bratislava, Slovak Republic

L Fuortes

Department of Preventive Medicine and Environmental Health, University of Iowa, Iowa City, Iowa 52242, USA

Styrene is an indispensable chemical extensively used in plastic and synthetic rubber industries. Styrene is known to produce various types of hepatotoxic, neurotoxic, and genotoxic effects. Styrene may be immunotoxic by both direct and indirect mechanisms. Measurement of adhesion molecules is a new tool for the investigation of immune system modulation. The aim of this study was to evaluate the association of the expression of the adhesion molecules CD11a, CD11b, CD18, CD54, CD49d, and CD62L in white blood cells and levels of soluble adhesion molecules ICAM-1 and L-selectin in serum with occupational exposure to styrene. Analyses by flow cytometry revealed elevated levels of most of the assessed adhesion molecules on surfaces of lymphocytes, monocytes, and granulocytes. Expression of the adhesion receptor antigens CD11a on lymphocytes, CD11b on monocytes, and CD18 on granulocytes were unaffected. Workers exposed to styrene had decreased concentrations of sICAM-1 and no changes in concentrations of sL-selectin. Styrene exposure appears to increase activation of the immune system and alter leukocyte adherence. This interaction is a critical first step in immune stimulation and leukocyte–endothelial interaction.

Key Words: adhesion molecules • immunotoxicity • styrene

Human & Experimental Toxicology, Vol. 21, No. 5, 235-240 (2002)
DOI: 10.1191/0960327102ht251oa
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