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Human & Experimental Toxicology
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Intrarectal administration of 5-aminosalicylic acid to rabbits and dogs

E L Berryman

LAB Pre-Clinical Research International Inc., 560 Cartier Boulevard West, Laval, Quebec, Canada H7V 1J1; berrymanl{at}preclin.com

A C Zerouala

LAB Pre-Clinical Research International Inc., 560 Cartier Boulevard West, Laval, Quebec, Canada H7V 1J1

C Meschter

Comparative BioSciences Inc., 2375 Garcia Avenue, Mountain View, California 94043, USA

J Spenard

Axcan Pharma Inc., 597 Boulevard Laurier, Mont St-Hiliare, Quebec, Canada J3H 6C4

Intrarectal administration of 5-aminosalicylic acid (5-ASA) to rabbits and dogs was performed to obtain safety data. Groups of rabbits and dogs received twice daily intrarectal doses of 250, 500 or 1000 mg 5-ASA for 14 consecutive days. Treatment had no adverse effect on the behaviour or performance of the animals and microscopic examination revealed no evidence of systemic or local toxicity.

Key Words: 5-ASA • mesalamine • salofalk • sulfasalazine • ulcerative colitis

Human & Experimental Toxicology, Vol. 21, No. 3, 159-163 (2002)
DOI: 10.1191/0960327102ht236oa
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