This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Stadtman, E R Articles by Levine, R L Search for Related Content PubMed PubMed Citation Articles by Stadtman, E R Articles by Levine, R L Social Bookmarking                         What's this?

Why have cells selected reactive oxygen species to regulate cell signaling events?

Laboratory of Biochemistry, NHLBI/NIH, 50 South Drive, Room 2140 (MSC 8012), Bethesda, Maryland 20892-8012, USA; stadtmae{at}nhlbi.nih.gov

R L Levine

Laboratory of Biochemistry, NHLBI/NIH, 50 South Drive, Room 2140 (MSC 8012), Bethesda, Maryland 20892-8012, USA

There is a growing body of evidence demonstrating that exposure of cells to reactive oxygen species (ROS) leads to oxidative modification of nucleic acids, proteins, and lipids, and that such modifications can contribute to the development of a number of diseases and aging. This raises the question: If ROS are so damaging to cells, why have cells selected ROS to trigger activation of so many cell signaling pathways?

Key Words: apoptosis • H2O2 • ROS

Human & Experimental Toxicology, Vol. 21, No. 2, 83 (2002)
DOI: 10.1191/0960327102ht215oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				C. Reyes-Moreno, E. Sharif-Askari, J. Girouard, C. Leveille, M. Jundi, A. Akoum, R. Lapointe, A. Darveau, and W. Mourad Requirement of Oxidation-dependent CD40 Homodimers for CD154/CD40 Bidirectional Signaling J. Biol. Chem., July 6, 2007; 282(27): 19473 - 19480. [Abstract] [Full Text] [PDF]

				M. A. S. Khan, P. B. Chock, and E. R. Stadtman Knockout of caspase-like gene, YCA1, abrogates apoptosis and elevates oxidized proteins in Saccharomyces cerevisiae PNAS, November 29, 2005; 102(48): 17326 - 17331. [Abstract] [Full Text] [PDF]

				M. A. S. Khan, H. Oubrahim, and E. R. Stadtman Inhibition of apoptosis in acute promyelocytic leukemia cells leads to increases in levels of oxidized protein and LMP2 immunoproteasome PNAS, August 10, 2004; 101(32): 11560 - 11565. [Abstract] [Full Text] [PDF]