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Comments on the article ‘Defining hormesis’, by EJ Calabrese and LA Baldwin

Environmental and Occupational Health Sciences Institute, 317 George Street, Suite 202, New Brunswick, New Jersey 08901, USA; acupton{at}eohsi.rutgers.edu

In view of the diversity of biological responses and the extent to which many of them remain poorly elucidated, there is merit in the suggestion by Calabrese and Baldwin that the term ‘hormesis’ should be applicable to those adaptive responses that are characterized by biphasic dose–response relationships, without reference to any associated beneficial or harmful effects. Whether the dose–response relationships for radiation-induced mutations and chromosome aberrations are biphasic in nature is an important question that remains to be resolved.

Key Words: dose-response • hormesis • low-dose • risk assessment • risk/benefit

Human & Experimental Toxicology, Vol. 21, No. 2, 111 (2002)
DOI: 10.1191/0960327102ht222oa


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