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The chelating treatment is not useful in human's intoxication with acute herbicidal organic arsenic

M-S Tsai

Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

J-L Tsai

Graduate Institute of Occupational Safety and Health, Kaohsiung Medical University, Kaohsiung, Taiwan

H-H Lee

Department of Laboratory, Kaohsiung Medical University, Kaohsiung, Taiwan

T-J Lin

Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung; School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC; tjlin{at}kmu.edu.tw

The clinical manifestations of acute organic arsenic intoxication in humans have seldom been described and the associated treatment has been thought to be the same as that of acute inorganic arsenic intoxication. We have studied a collection of patients from 1996 to 2001 who called the Poison Control Center of Kaohsiung Medical University Hospital asking for information regarding acute organic arsenic intoxication. The 17 patients ranged in age from 23 to 64 years old, with 5 females and 12 males. The cause of arsenic ingestion was attempted suicide. Abdominal pain and vomiting were the main symptoms. There were no differences in results between patients treated with and those treated without chelating agents. We therefore believe that the results of acute organic intoxication are not same as acute inorganic intoxication and it is unnecessary to use chelating agents in such conditions.

Key Words: arsenic • chelating agents • herbicide • organic arsenic

Human & Experimental Toxicology, Vol. 21, No. 12, 631-634 (2002)
DOI: 10.1191/0960327102ht306oa


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